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题名:Controversial Marrow Cells Coming Into Their Own?
作者:Constance Holden
来源:Science[IF=30.927]. 9 February 2007: Vol. 315. no. 5813, pp. 760 - 761, News Focus
URL :http://dx.doi.org/10.1126/science.315.5813.760
日期:070330
摘要: Constance Holden

Article

Catherine Verfaillie of the University of Minnesota made a big splash in 2002 when she reported in Nature that her lab had cultivated a type of cell with some seemingly remarkable properties. Called multipotent adult progenitor (MAP) cells and derived from the stromal cells of the bone marrow, the cells seemed to be able to turn into "most, if not all" cell types, the team wrote. And when injected into a mouse embryo, they appeared to contribute to most somatic cell types, creating a so-called chimeric mouse. MAP cells were surprisingly versatile for adult cells, whose fates were generally believed to be predetermined--in fact, they looked almost as good as embryonic stem (ES) cells.

Although Verfaillie was cautious in her claims, the press seized on MAP cells as an alternative to ES cells, which are controversial because creating them involves the destruction of an embryo. Scientists, too, were eager to try them out. But in the years since, MAP cells have failed to live up to expectations. They proved hard to grow, and the talk over coffee at meetings was that no one could replicate the Nature work.... 6

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