详细记录  
题名:Regulation of MDK expression in human cancer cells modulates sensitivities to various anticancer drugs: MDK overexpression confers to a multi-drug resistance
作者:Hio Chung Kang, Il-Jin Kim, Hye-Won Park, Sang-Geun Jang, Sun-A Ahn, Sang Nam Yoon, Hee-Jin Chang, Byong Chul Yoo and Jae-Gahb Park
来源:Cancer Letters[IF=3.049], Volume 247, Issue 1, 8 March 2007, Pages 40-47
URL :http://dx.doi.org/10.1016/j.canlet.2006.03.017
日期:070415
摘要: Hio Chung Kanga, c, 1, Il-Jin Kima, 1, Hye-Won Parka, Sang-Geun Janga, Sun-A Ahna, Sang Nam Yoonb, Hee-Jin Changc, Byong Chul Yooc and Jae-Gahb Parka, b, c, ,

aKorean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University, Seoul 110-799, South Korea
bDepartment of Surgery, Seoul National University College of Medicine, Seoul 110-799, South Korea
cResearch Institute and Hospital, National Cancer Center, Goyang, 411-764 Gyeonggi, South Korea

Received 4 October 2005; revised 12 December 2005; accepted 16 March 2006. Available online 27 April 2006.

Summary

MDK is a heparin-binding growth factor associated with cancer development. Here, we sought to examine the association of MDK expression with resistance and sensitivity to different chemotherapeutic agents. We established stable HeLa cell transfectants (HeLaCMDK) and tested for decreased sensitivity to chemotherapeutic agents (5-FU, doxorubicin, and cisplatin). In addition, we used siRNA to block MDK expression in SNU-638 human gastric cancer cells and examined the chemosensitizing effect. HeLaCMDK cells treated with 5-FU, doxorubicin, and cisplatin showed a fold increase in the average IC50 and an increased cell survival. siRNA-based knockdown of MDK expression in SNU-638 cells decreased the average IC50 by 18C44% in cells treated with three drugs. Further investigations on the molecular mechanism should be clarified, but these results indicate that MDK up- and down-regulation appears to be capable of changing the chemosensitivities of cancer cells and MDK may have possible importance as a candidate therapeutic molecule. 15.

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