题名：Identification of trophinin as an enhancer for cell invasion and a prognostic factor for early stage lung cancer
作者：Kuan-Yu Chen, Yuan-Chii Gladys Lee, Jin-Mei Lai, Yih-Leong Chang, Yung-Chie Lee, Chong-Jen Yu, Chi-Ying F. Huang and Pan-Chyr Yang
来源：European Journal of Cancer[IF=3.706], Volume 43, Issue 4, March 2007, Pages 782-790
摘要： Kuan-Yu Chena, Yuan-Chii Gladys Leed, Jin-Mei Laie, Yih-Leong Changb, Yung-Chie Leec, Chong-Jen Yua, Chi-Ying F. Huangf, , and Pan-Chyr Yanga, ,
aDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
bDepartment of Pathology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
cDepartment of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
dGraduate Institute of Medical Informatics, Taipei Medical University, Taipei, Taiwan
eDepartment of Life Science, Fu-Jen Catholic University, Taipei Hsien, Taiwan
fNational Institute of Cancer Research, National Health Research Institutes, Taipei, Taiwan
Received 8 July 2006; accepted 7 September 2006. Available online 24 January 2007.
The explosion of microarray studies has promised to shed light on the identification of disease markers. To find novel prognostic factors, we used the expression profile of a poor prognostic factor of lung cancer, survivin (BIRC5), as a template to search for and compare transcriptome expression profiles in a lung adenocarcinoma microarray dataset. Trophinin (TRO) was identified as one of the best-correlated genes. The trophinin expression in lung cancer specimens was examined by immunohistochemical staining. The role of trophinin in cancer metastasis was further investigated by approaches of overexpression and knock down with small interfering RNA (siRNA). For stage I lung adenocarcinoma, the patients without trophinin expression had a better overall and disease-free survival. Overexpression of trophinin increases cell invasion ability and knock down with siRNA inhibits cell invasion. Through a combination of data mining and biochemical assays, we identified trophinin, which could enhance cell invasion, as a novel prognostic factor for early stage lung cancer. 17.
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