详细记录  
题名:Invertebrate preparations and their contribution to neurobiology in the second half of the 20th century
作者:Fran?ois Clarac and Edouard Pearlstein
来源:Brain Research Reviews[IF=6.402], Volume 54, Issue 1, April 2007, Pages 113-161
URL :http://dx.doi.org/10.1016/j.brainresrev.2006.12.007
日期:070415
摘要: Fran?ois Clarac, a, and Edouard Pearlsteina

aP3M, CNRS, Universit de la Mditerrane, 31 chemin Joseph Aiguier, 13402 Marseille, cedex 20, France

Accepted 27 December 2006. Available online 12 January 2007.

Summary

This review summarizes the contribution to neurobiology achieved through the use of invertebrate preparations in the second half of the 20th century. This fascinating period was preceded by pioneers who explored a wide variety of invertebrate phyla and developed various preparations appropriate for electrophysiological studies. Their work advanced general knowledge about neuronal properties (dendritic, somatic, and axonal excitability; pre- and postsynaptic mechanisms). The study of invertebrates made it possible to identify cell bodies in different ganglia, and monitor their operation in the course of behavior. In the 1970s, the details of central neural circuits in worms, molluscs, insects, and crustaceans were characterized for the first time and well before equivalent findings were made in vertebrate preparations. The concept and nature of a central pattern generator (CPG) have been studied in detail, and the stomatogastric nervous system (STNS) is a fine example, having led to many major developments since it was first examined. The final part of the review is a discussion of recent neuroethological studies that have addressed simple cognitive functions and confirmed the utility of invertebrate models. After presenting our invertebrate mice, the worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster, our conclusion, based on arguments very different from those used fifty years ago, is that invertebrate models are still essential for acquiring insight into the complexity of the brain. 2.

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]