详细记录  
题名:Spatio-temporal expression of Prospero is finely tuned to allow the correct development and function of the nervous system in Drosophila melanogaster
作者:Laure Guenin, Ya?l Grosjean, Stphane Fraichard, Angel Acebes, Fawzia Baba-Aissa and Jean-Fran?ois Ferveur
来源:Developmental Biology[IF=5.234], Volume 304, Issue 1, 1 April 2007, Pages 62-74
URL :http://dx.doi.org/10.1016/j.ydbio.2006.12.016
日期:070415
摘要: Laure Guenina, 1, Ya?l Grosjeana, c, 1, Stphane Fraicharda, Angel Acebesb, Fawzia Baba-Aissaa, , and Jean-Fran?ois Ferveura

aUnit Mixte de Recherche 5548 Associe au Centre National de la Recherche Scientifique, Universit de Bourgogne, 6, Bd Gabriel, 21 000 Dijon, France
bDepartamento de Neurobiologa del Desarrollo, Instituto Cajal de Neurobiologa, Avda. Dr. Arce 37, 28002 Madrid, Spain
cDepartment of Biological Sciences, University of Illinois at Chicago, 950 S Halsted, Chicago, IL 60607, USA

Received 24 April 2006; revised 5 December 2006; accepted 8 December 2006. Available online 12 December 2006.

Summary

Adaptive animal behaviors depend upon the precise development of the nervous system that underlies them. In Drosophila melanogaster, the pan-neural prospero gene (pros), is involved in various aspects of neurogenesis including cell cycle control, axonal outgrowth, neuronal and glial cell differentiation. As these results have been generally obtained with null pros mutants inducing embryonic lethality, the role of pros during later development remains poorly known. Using several pros-Voila (prosV) alleles, that induce multiple developmental and behavioral anomalies in the larva and in adult, we explored the relationship between these phenotypes and the variation of pros expression in 5 different neural regions during pre-imaginal development. We found that the quantity of pros mRNA spliced variants and of Pros protein varied between these alleles in a tissue-specific and developmental way. Moreover, in prosV1 and prosV13 alleles, the respective decrease or increase of pros expression, affected (i) neuronal and glial cell composition, (ii) cell proliferation and death and (iii) axonal-dendritic outgrowth in a stage and cellular context dependant way. The various phenotypic consequences induced during development, related to more or less subtle differences in gene expression, indicate that Pros level needs a precise and specific adjustment in each neural organ to allow its proper function. 3.

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