详细记录  
题名:Impaired motor functions in mice lacking the RNA-binding protein Hzf
作者:Takatoshi Iijima, Hiroo Ogura, Kanako Takatsuki, Shigenori Kawahara, Kenichiro Wakabayashi, Daisuke Nakayama, Masato Fujioka, Yuki Kimura, Alan Bernstein, Hirotaka James Okano, et al.
来源:Neuroscience Research[IF=2.184], In Press, Corrected Proof, Available online 28 February 2007,
URL :http://dx.doi.org/10.1016/j.neures.2007.02.013
日期:070415
摘要: Takatoshi Iijimaa, Hiroo Ogurac, Kanako Takatsukid, Shigenori Kawaharad, Kenichiro Wakabayashia, b, Daisuke Nakayamaa, Masato Fujiokaa, b, Yuki Kimurae, Alan Bernsteine, Hirotaka James Okanoa, Yutaka Kirinod and Hideyuki Okanoa, ,

aDepartment of Physiology, School of Medicine, Keio University, Shinjyuku, Tokyo 160-8582, Japan
bDepartment of Otolatoryngology, Head and Neck Surgery, School of Medicine, Keio University, Shinjyuku, Tokyo 160-8582, Japan
cTsukuba Research laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki 300-2635, Japan
dLaboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan
eSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada

Received 14 December 2006; accepted 21 February 2007. Available online 28 February 2007.

Summary

Local protein synthesis in dendrites plays an important role in some aspects of neuronal development and synaptic plasticity. Neuronal RNA-binding proteins regulate the transport and/or translation of the localized mRNAs. Previously, we reported that hematopoietic zinc finger (Hzf) is one of the neuronal RNA-binding proteins that regulate these processes. The Hzf protein is highly expressed in neuronal cells including hippocampal pyramidal neurons and cerebellar Purkinje cells, and plays essential roles in the dendritic mRNA localization and translation. In the present study we demonstrated that mice lacking Hzf (Hzf ?/? mice) exhibited severe impairments of motor coordination and cerebellum-dependent motor learning. These findings raise the possibility that the post-transcriptional regulation by Hzf may contribute to some aspects of synaptic plasticity and motor learning in the cerebellum. 8ku 2:

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