详细记录  
题名:Potentially toxic effects of anaesthetics on the developing central nervous system.
作者:Gascon E, Klauser P, Kiss JZ, Vutskits L.
来源:Eur J Anaesthesiol[IF=----]. 2007 Mar;24(3):213-24. Epub 2007 Jan 30.
URL :http://dx.doi.org/10.1017/S0265021506002365
日期:070415
摘要: E. Gascon a1, P. Klauser a1, J. Z. Kiss a1 and L. Vutskits a1c1

a1 University of Geneva Medical School, Department of Anesthesiology, Pharmacology and Intensive Care, Geneva, Switzerland

Summary

A growing body of experimental evidence suggests that anaesthetics, by influencing GABAergic and glutaminergic neural signalling, can have adverse effects on the developing central nervous system. The biological foundation for this is that gamma-aminobutyric acid and glutamate could act non-synaptically, in addition to their role in neurotransmission in the adult brain, in the regulation of neuronal development in the central nervous system. These neurotransmitters and their receptors are expressed from very early stages of central nervous system development and appear to influence neural progenitor proliferation, cell migration and neuronal differentiation. During the synaptogenetic period, pharmacological blockade of N-methyl-D-aspartate (NMDA)-type glutamate receptors as well as stimulation of GABAA receptors has been reported to be associated with increased apoptosis in the developing brain. Importantly, recent data suggest that even low, non-apoptogenic concentrations of anaesthetics can perturb neuronal dendritic development and thus could potentially lead to impairment of developing neuronal networks. The extrapolation of these experimental observations to clinical practice is of course very difficult and requires extreme caution as differences in drug concentrations and exposure times as well as interspecies variations are all important confounding variables. While clinicians should clearly not withhold anaesthesia based on current animal studies, these observations should urge more laboratory and clinical research to further elucidate this

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]