详细记录  
题名:Neural Ensemble Coding of Satiety States
作者:Ivan E. de Araujo, Ranier Gutierrez, Albino J. Oliveira-Maia, Antonio Pereira, Miguel A.L. Nicolelis, and Sidney A. Simon
来源:Neuron 2006 51: 483-494.
URL :http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSS-4KNCRDC-C&_coverDate=08%2F17%2F2006&_alid=449082055&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=7054&_sort=d&view=c&_acct=C000058795&_version=1&_urlVersion=0&_userid=2787589&md5=3acd6815c096a9863e72115c98cd281a
日期:060930
摘要:The motivation to start or terminate a meal involves the continual updating of information on current body status by central gustatory and reward systems. Previous electrophysiological and neuroimaging investigations revealed region-specific decreases in activity as the subject`s state transitions from hunger to satiety. By implanting bundles of microelectrodes in the lateral hypothalamus, orbitofrontal cortex, insular cortex, and amygdala of hungry rats that voluntarily eat to satiety, we have measured the behavior of neuronal populations through the different phases of a complete feeding cycle (hunger-satiety-hunger). Our data show that while most satiety-sensitive units preferentially responded to a unique hunger phase within a cycle, neuronal populations integrated single-unit information in order to reflect the animal`s motivational state across the entire cycle, with higher activity levels during the hunger phases. This distributed population code might constitute a neural mechanism underlying meal initiation under different metabolic states

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]