详细记录  
题名:Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease
作者:Luis Enjuanes, Marta L. DeDiego, Enrique lvarez, Damon Deming, Tim Sheahan and Ralph Baric
来源:Virus Research[IF=2.562], In Press, Corrected Proof, Available online 9 April 2007,
URL :http://dx.doi.org/10.1016/j.virusres.2007.01.021
日期:070415
摘要: Luis Enjuanesa, , , Marta L. DeDiegoa, Enrique lvareza, Damon Demingb, Tim Sheahanb and Ralph Baricb,

aCentro Nacional de Biotecnologa (CNB), CSIC, Campus Universidad Autnoma, Cantoblanco, Darwin 3, 28049 Madrid, Spain
bDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, 802 Mary Ellen Jones Building, Chapel Hill, NC 27599-7290, USA

Available online 9 April 2007.

Summary

An important effort has been performed after the emergence of severe acute respiratory syndrome (SARS) epidemic in 2003 to diagnose and prevent virus spreading. Several types of vaccines have been developed including inactivated viruses, subunit vaccines, virus-like particles (VLPs), DNA vaccines, heterologous expression systems, and vaccines derived from SARS-CoV genome by reverse genetics. This review describes several aspects essential to develop SARS-CoV vaccines, such as the correlates of protection, virus serotypes, vaccination side effects, and bio-safeguards that can be engineered into recombinant vaccine approaches based on the SARS-CoV genome. The production of effective and safe vaccines to prevent SARS has led to the development of promising vaccine candidates, in contrast to the design of vaccines for other coronaviruses, that in general has been less successful. After preclinical trials in animal models, efficacy and safety evaluation of the most promising vaccine candidates described has to be performed in humans. 12.

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