详细记录  
题名:SARS epidemiologyFrom descriptive to mechanistic analyses
作者:Guo-Ping Zhao
来源:Virus Research[IF=2.562], In Press, Corrected Proof, Available online 6 March 2007,
URL :http://dx.doi.org/10.1016/j.virusres.2007.01.010
日期:070415
摘要: Guo-Ping Zhao, a,

aLaboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, National Engineering Center for BioChip at Shanghai, Zhangjiang HiTech Park, Pudong, Shanghai 201203, China

Available online 6 March 2007.

Summary

Severe acute respiratory syndrome (SARS) was the first natural disaster that challenged the humanity at the beginning of the 21st century, which was caused by a novel animal coronavirus named as SARS coronavirus (SARS-CoV). This virus exploited opportunities provided by wet markets in southern China to adapt to palm civet and human. Under the positive selection pressure of human host, certain mutated lineages of the virus became readily transmissible between humans and thus caused the epidemic of 2002C2003. This review will provide the first hand information, particularly from Guangdong, China, about the initial descriptive epidemiology, the identification of the etiological agent of the disease, the molecular evolution study of the virus, the finding of SARS-like coronavirus in horseshoe bats and the mechanistic analysis for the cross-host tropism transition. The substantial contributions made by the Chinese scientists towards understanding the epidemiology and the mechanism of the viral evolution unpublished or published in Chinese will be emphasized. This review is aimed to appreciate the concerted and coordinated global response that controlled SARS within a short period of time as well as the research strategy and methodology developed along with this process, which can be applied in response to other public health challenges, particularly, the future emerging/re-merging infectious diseases. 25.

================  评  论  部  分=================

重要性:
分类:(参照 Faculty of 1000 的分类体系)


评语:

评论密码:   返回前页  [全部]