详细记录  
题名:Regulation of natural killer cell activity
作者:Sheryl E Kirwan and Deborah N Burshtyn
来源:Current Opinion in Immunology, Volume 19, Issue 1, February 2007, Pages 46-54
URL :http://dx.doi.org/10.1016/j.coi.2006.11.012
日期:070215
摘要:Sheryl E Kirwana and Deborah N Burshtyna,

aDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2S2, Canada

Available online 4 December 2006.

Summary

Information regarding the role of natural killer (NK) cells in the response to viruses, intracellular bacteria and parasites continues to emerge. NK cells can directly lyse infected cells, secrete cytokines and interact with dendritic cells to drive the adaptive immune response. There are a large number of activating and inhibitory receptors that govern NK cell activity. Recent studies have revealed how signals are transmitted and integrated from the variety of receptors, how particular receptors influence NK development and functional status, and how NK cells access lymph nodes and sites of infection. The potential for NK cells to exhibit specific and memory-like responses has begun to blur the ‘innate’ definition of NK cells.

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