详细记录  
题名:Dynamic Programing of CD8+ T Cell Trafficking after Live Viral Immunization
作者:Luzheng Liu, Robert C. Fuhlbrigge,...
来源:Immunity 2006 25: 511-520.
URL :http://dx.doi.org/10.1016/j.immuni.2006.06.019
日期:061215
摘要:Luzheng Liu1, 2, , , Robert C. Fuhlbrigge1, 2, Kara Karibian1, Tian Tian1, 2 and Thomas S. Kupper1, 2, ,

1Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women`s Hospital, Boston, Massachusetts 02115
2Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02115


Summary

After viral infection, activated T cells are present in multiple tissues regardless of the infection route. How these cells acquire pleiotropic homing ability is unclear. By using a cutaneous vaccinia virus infection model, we demonstrate that regulation of T cell trafficking is multiphasic. Upon completion of three cell divisions, CD8+ T cells upregulated specific skin-homing molecules within draining lymph nodes (LN). By 60 hr after infection, some activated T cells reached the infected tissue, while others entered distant antigen-free LN. These latter cells continued to divide and acquire additional tissue-homing molecules in this new setting, independent of antigen presentation. After viral clearance, the initial skin-homing imprint became the predominant homing phenotype on memory cells and provided superior protection against secondary cutaneous challenge. These observations demonstrate a mechanism by which T cells provide both immediate tissue-specific immune control at the pathogen entry site and a more flexible systemic protection against pathogen dissemination.

The non-TLR innate immune receptors and/or sensors discussed in this Focus might seem too dissimilar for a `unified picture` of innate immunity to be painted. An important aim of this Focus is to highlight four families of innate proteins that span diverse organisms, from nematodes to plants to humans, and to show how these molecules variously contribute to innate immunity. The unified picture derives from viewing the innate immune system as a potential `network` that can distinguish between `friend` (commensal bacteria) and `foe` (pathogenic bacteria). Although there is no doubt that the complete picture of the innate signaling network is yet to be fully described, many pieces of the puzzle are falling into place.

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