|目录: ||Diagnoses termed `cancer` consist of hundreds of different diseases with as many constellations of genetic alterations. Genomic technologies have made it possible to identify all of the tumor-specific mutations, to profile individual tumors at the DNA, RNA, and protein levels, and to test in cellular and animal systems the responses of particular genotypes to particular drugs. Oncogenomics and allied disciplines have identified new targets for genotype-specific treatments and provided strategies to validate these targets and to develop drugs. With the potential need to stratify patients by genotype, clinical testing of targeted drugs has become more complicated while expectations of patients, investors, and funding agencies have become accelerated. Oncogenomics: Molecular Approaches to Cancer offers the first rigorous yet broadly accessible treatment of the impact of genomics on cancer research and care. Clearly written by world-renowned scientists in the field, and edited for overall cohesion, Oncogenomics progresses logically from molecular profiling to model systems, cancer pharmacology, and clinical trials. Oncogenomics *Covers cutting-edge issues such as array-based diagnostics, pharmaco-genomics, and molecularly targeted therapeutics *Includes discussions of ethical, legal, and social issues related to cancer genomics and clinical trials *Provides links to online oncogenomic resources and references
Recognizing the multidisciplinary character of Oncogenomics, the editors include an advanced introduction to cancer genetics and cancer pharmacology that makes accessible state-of-the-art topics such as expression profiling, SNPs in cancer, tissue microarrays, and chemical and genetic validation studies. Scientists, oncologists, and other healthcare professionals, as well as advanced students, will find Oncogenomics an essential resource for elucidating this exciting field.