|目录: ||As cancer research increasingly becomes an applied science, academic and biotech researchers interested in general principles must think more about how their efforts translate into the clinical arena. At the same time, researchers on the industrial side stand to gain from a better understanding of the latest strategies for target and lead drug discovery. This way the great promise of new approaches to cancer drug development&*150;preventions and treatments that will be less toxic and more effective than current drugs through targeting specific molecular features of aberrant cells&*150;can finally be fulfilled.
Molecular Cancer Therapeutics: Strategies for Drug Discovery and Development offers an up-to-date overview of the different phases of drug discovery and preclinical development of new experimental cancer principles. In tying together the diverse set of disciplines and methods involved in these pursuits, the text covers: *Discovery and validation of drug targets *Drug screening *Animal models *Preclinical testing *Pharmacology issues *Clinical concerns *Intellectual property issues
Directed to a broad audience of students and professionals in academia and industry, Molecular Cancer Therapeutics provides a comprehensive summary of state-of-the-art strategies for identifying drug targets and developing lead inhibitors. With its coverage of target validation, drug screening, and pharmacokinetics, it is an invaluable reference for those working in oncology as well as the broad range of disciplines concerned with drug discovery and development.