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ISBN: 0306485060
题名: Biomedical EPR - Part A: Free Radicals, Metals, Medicine and Physiology
作者: Sandra S. Eaton ; Gareth R. Eaton
出版社: Kluwer
页数: 536p
价格: EUR : 179.95
当前票数: 3
预版日期: 2004-1-1 0:00:00
文摘: Prof. Sandra S. Eaton is John Evans Professor in the Department of Chemistry and Biochemistry at the University of Denver. Her research interests include distance measurements in proteins, EPR of metal ions in biological systems, electron spin relaxation times, and EPR instrumentation. The Eatons co-organize an annual EPR Symposium in Denver. Prof. Gareth R. Eaton is John Evans Professor in the Department of Chemistry and Biochemistry at the University of Denver. His research interests include EPR instrumentation, distance measurements in proteins, EPR of metal ions in biological systems, and electron spin relaxation times. Dr. Lawrence J. Berliner is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979. Biomedical EPR – Part A focuses on applications of EPR spectroscopy in the areas of free radicals, metals, medicine, and physiology. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field which lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features:Free Radicals in Medicine Radicals in vivo and in Model Systems, and their Study by Spin Trapping In vivo EPR, including Oximetry and Imaging Time Domain EPR at Radio Frequencies EPR of Copper Complexes: Motion and Frequency Dependence Time Domain EPR and Electron Spin Echo Envelope Modulation 目次 Section I. Instrumentation and Methodology Chapter 1 Saturation Recovery EPR Sandra S. Eaton and Gareth R. Eaton 1. Motivation 3 2. Brief History 4 3. Information Content of Saturation Recovery Curves 5 4. Practical Aspects of Experimental Methodology 5 5. Applications 10 6. Prognosis 15 7. References 15 Chapter 2 Loop-Gap Resonators George A. Rinard and Gareth R. Eaton 1. Introduction 19 2. History 20 3. Why should one use loop-gap resonators? 22 4. Basics 23 5. Topologies of loop gap resonators 25 6. Coupling to Resonators 29 7. Design equations 31 8. Magnetic Field Modulation 35 9. LGR for Time Domain EPR 36 10. Selection of the Q of a LGR 40 11. Measuring B1 in the LGR 42 12. Variable Temperature 44 13. Mechanical Considerations 44 14. Commercial Resonators 45 15. Applications of Lumped-Circuit Resonators 45 16. Further information 47 17. References 47 Chapter 3 EPR Interfaced To Rapid Mixing Charles P. Scholes 1. Introduction 53 2. The Loop Gap Resonator Based Stopped-Flow System 55 3. Dielectric Resonator-based Stopped-Flow EPR 62 4. Applications of Stopped-Flow and Flow EPR to Naturally Occurring Transient Radicals 79 5. Future Developments and Applications of Flow and Stopped-Flow EPR 83 6. References 84 Chapter 4 Application of Angle-Selected Electron Nuclear Double Resonance to Characterize Structured Solvent in Small Molecules and Macromolecules Devkumar Mustafi and Marvin W. Makinen 1. Introduction 89 2. ENDOR Assignment of Molecular Structure and Conformation with VO2+ and Nitroxyl Spin-Labels 93 3. ENDOR Characterization of Structured Solvent in Small Molecule Complexes and in Proteins 102 4. Future Perspectives and Concluding Remarks 132 5. References 135 Chapter 5 Solution-ENDOR of Some Biologically Interesting Radical Ions Fabian Gerson and Georg Gescheidt 1. Solution ENDOR Spectroscopy 145 2. Quinones 152 3. Porphyrinoids 157 4. References 162 Chapter 6 Electron-Electron Double Resonance Lowell D. Kispert 1. Introduction 165 2. Instrumental Techniques 171 3. Dynamics of Biomolecules in Liquid Crystals, Glassy Solids, Polymers and Crystals 180 4. Practical Aspects of Measurements 186 5. References 187 Chapter 7 Digital Detection by Time-Locked Sampling in EPR James S. Hyde, Theodore G. Camenisch, Joseph J. Ratke, Robert A. Strangeway, Wojciech Froncisz 1. Introduction 199 2. Time Locking and Superheterodyne Detection – EPR Instrument Design Background 203 3. Time-Locked Subsampling Detection for CW EPR 204 4. Pulse Saturation Recovery Using Time-Locked Subsampling 209 5. Selected Engineering Considerations 212 6. Conclusion 220 7. References 221 Chapter 8 Measurement of Distances Between Electron Spins Using Pulsed EPR Sandra S. Eaton and Gareth R. Eaton 1. Introduction 223 2. Fundamental Principles of Interaction between Electron Spins 224 3. Distance between Two Slowly Relaxing Centers 227 4. Distance between a Slowly Relaxing Center and a Rapidly-Relaxing Center 228 5. Some Practical Considerations 229 6. Recent Examples for Distances between Two Slowly-Relaxing Radicals 230 7. Recent Examples for Distances between a Rapidly-Relaxing and a Slowly-Relaxing Spin 232 8. Prognosis 234 9. References 235 Section II. Motion, Proteins, and Membranes Chapter 9 ESR and Molecular Dynamics Jack H. Freed 1. Motional Narrowing and Organic Radicals 239 2. Double Resonance and Molecular Dynamics 241 3. Slow Motional ESR and Molecular Dynamics 242 4. High Field ESR and Molecular Dynamics 246 5. Spin-Echoes and Molecular Dynamics 251 6. Two-Dimensional Fourier Transform ESR 256 7. Prospectus 263 8. Glossary of Abbreviations 264 9. References 264 Chapter 10 SDSL: A Survey of Biological Applications Candice S. Klug and Jimmy B. Feix 1. Introduction 269 2. Solvent accessibility 271 3. Motion 280 4. Distance measurements 290 5. Methodology 298 6. Conclusion 300 7. References 300 Chapter 11 Saturation Transfer Spectroscopy of Biological Membranes Derek Marsh, László I. Horváth, Tibor Páli And Vsevolod A. Livshits 1. Introduction 309 2. Historical Development 311 3. Rapid-Passage Saturation-Transfer-EPR Displays 313 4. Modulation-Coupled Bloch Equations 315 5. Slow Rotational Diffusion 320 6. Applications: Slow Rotation 324 7. T1-Sensitive Nonlinear EPR Displays 331 8. Slow Exchange and Paramagnetic Enhancements 339 9. Applications: Relaxation Enhancements 348 10. Outlook 358 11. References 363 Chapter 12 Saturation Transfer EPR: Rotational Dynamics of Membrane Proteins Albert H. Beth and Eric J. Hustedt 1. Introduction 369 2. Methods for Analysis of ST-EPR Data 373 3. Overview of Theory for Calculation of ST-EPR Spectra 376 4. Nonlinear Least Squares Methods of Data Analysis 382 5. Model Calculations of ST-EPR Spectra Using the Transition Rate Matrix Approach 383 6. Applications of ST-EPR to Membrane Proteins 396 7. References 401 Chapter 13 Trends in EPR Technology James S. Hyde 1. Introduction 409 2. Resonators 410 3. Noise 415 4. Multifrequency EPR 420 5. EPR for Routine Analysis 423 6. Discussion 425 7. References 426 Chapter 14 Prognosis Sandra S. Eaton and Gareth R. Eaton Contents of Previous Volumes Index
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