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ISBN: 0387985875
题名: Principles of Protein X-Ray Crystallography
作者: Drenth, Jan
出版社: Springer
页数: 351p
价格: EUR : 80.20
当前票数: 51
预版日期: 1999-1-1 0:00:00
文摘: 16X-ray crystallography has been a vital method for studying the structure of proteins and other macromolecules for many years. As the importance of proteins continues to grow in a wide range of research fields form basic biochemistry and biophysics to pharmaceutical development and biotechnology, more and more researchers have found a knowledge of X-ray diffraction to be an indispensable tool. Professor Drenth, recognized internationally for his numerous contributions to crystallographic research, has provided a technically rigorous introduction to the subject. This book provides the theoretical background necessary to understand how the structures of proteins is determined at atomic resolution. It is intended to be an introduction for graduate students, postdoctoral researchers, and established scientists who want to apply protein crystallography in their own endeavors, or need to understand the subject in order to critically evaluate the literature. 07Principles of Protein X-ray Crystallography is appropriate as a textbook for courses in biochemistry and biophysics, including protein structure and function, structural biology, and macromolecular structure. 07This new addition to the widely-respected Springer Advanced Texts in Chemistry series is an affordable, up-to-date introduction to the principles of this field. Protein crystallography is vital to research in biophysics, biochemistry/molecular biology, and drug development. The author is an internationally-recognized expert on the topic. 04From the contents:- Crystallizing a Protein- X-ray Sources and Detectors- Crystals- The Theory of X-ray Diffraction by a Crystal- Average Reflection Intensity and Distribution of Structure Factor Data- Special Forms of the Structure Factor- The Solution of the Phase Problem by the Isomorphous Replacement Method- Phase Improvement- Anomalous Scattering in the Determination of the Protein Phase Angles and the Absolute Determination- Molecular Replacement- Direct Methods 目次 Crystallizing a Protein.- X-ray Sources and Detectors.Crystals.- The Theory of X-ray Diffraction by a Crystal.Average Reflection Intensity and Distribution of Structure Factor Data.- Special Forms of the Structure Factor.- The Solution of the Phase Problem by the Isomorphous Replacement Method.- Phase Improvement.- Anomalous Scattering in the Determination of the Protein Phase Angles and the Absolute Determination.- Molecular Replacement.- Direct Methods.
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