|文摘: ||During the past decade research into the pharmacology of cognition, particularly regarding learning and memory, has supported the concept that many potential neural targets exist for the development of cognitive-enhancing drugs. Whereas the main impetus for this research has been the ever growing population of individuals with dementing disorders such as Alzheimer`s disease, attention is also being focused on issues relating to cognitive impairment associated with `normal` aging. This book is useful as a source of information for making informed decisions regarding the relative utility and attributes of the various neural targets that have been studied to date.
Jerry J. Buccafusco: The cholinergic hypothesis - past and present.- Ezio Giacobini: Drugs that target cholinesterases.- William S. Messer, Jr.: Drugs that target muscarinic cholinergic receptors.- Andrea Wevers and Diana S. Woodruff-Pak: Rationale and prospects for drugs that target nicotinic acetylcholine receptors.- Edward D. Levin: Drugs that target catechoaminergic receptors.- Alvin V. Terry, Jr.: Drugs that target serotonergic receptors.- Thomas Weiser: Drugs that target amino acid receptors.- Arthur A. Hancock and Gerard B. Fox: Drugs that target histaminergic receptors.- Joe L. Martinez, Jr., Kenira Thompson, Melanie McFadyen and Stephen C. Heinrichs: Peptide and steroid hormone receptors as drug targets for enhancement of learning and memory performance.- Keith A. Wesnes, Andrea Zangara, Andrew Scholey and David Kennedy: Natural products as cognition enhancing agents.- Jerry J. Buccafusco and Moussa B.H. Youdim: Drugs with multiple CNS targets.- Index.